Maria Giovanna Di Trani earned a Master's degree in Physics from Sapienza University of Rome in 2016 with a thesis on diffusion MRI for prostate cancer diagnosis. She is currently enrolled in the PhD course in Morphogenesis and Tissue Engineering and studies different diffusion MRI for prostate cancer identification and grading. She worked on ex-vivo experiments for validation of diffusion models, such as Kurtosis and Anomalous Diffusion. Moreover, she is interested in prenatal imaging, studying brain development in fetuses and ventriculomegalias. Since July 2018 she has been working for the Enrico Fermi Centre and from January 2019 she will move to the Centre for Magnetic Resonance Resonance Research (CMRRR) in Minneapolis as an exchange student of the European RISE project. The aim of this project will be to study human brain aging with diffusion techniques, particularly sensitive to tissue microstructures, and to compare diffusion investigation outcomes with functional MRI data.
Publications
Articles
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Di Trani MG, Nezzo M, Caporale A, Miano R, Mauriello A, Bove P, Manenti G, Capuani S. Performance of Diffusion Kurtosis Imaging Versus Diffusion Tensor Imaging in Discriminating Between Benign Tissue, Low and High Gleason Grade Prostate Cancer. Academic Radiology, in press.
Nezzo MG, Di Trani MG, Caporale A, Miano R, Mauriello A, Bove P, Capuani S, Manenti G. Mean diffusivity discriminates between prostate cancer with grade group 1&2 and grade groups equal to or greater than 3. European Journal of Radiolory (2016), vol.85, p.1794-1801, ISSN: 1872-7727, doi: http://dx.doi.org/10.1016/j.ejrad.2016.08.001
Posters
Di Trani MG, Caporale A, Nezzo M, Capuani S. Towards a definition of the biophysical bases of transient Anomalous Diffusion (TAD) parameters. Evaluation of tAD, DKI and DTI in normal and cancer prostate tissue with Magnetic Resonance micro-imaging at 9.4 Tesla. In: Proceedings of the ISMRM-ESMRMB annual meeting (2018).
Di Trani MG, Manganaro L, Antonelli A, Guerreri M, De Feo R, Bernardo S, Catalano C, Capuani S. Apparent diffusion coefficient values of the normal foetal brain developing. In: Federico Giove. Editorial: Proceedings of the International School on Magnetic Resonance and Brain Function - XII Workshop. Frontiers in Physics. 23-27 May (2018).
Di Trani MG, Caporale A, Nezzo M, Miano R, Mauriello A, Bove P, Capuani S, Manenti G. Histogram analysis of low- and high-risk prostate cancer: a comparison between Gaussian and non-Gaussian diffusion. In: Magnetic Resonance Materials in Physics, Biology and Medicine (2017) vol.30.
Di Trani MG, Caporale A, Nezzo M, Miano R, Mauriello A, Bove P, Manenti G, Capuani S. Mean Kurtosis discriminates between low- and high-risk prostate cancer better than Mean Diffusivity does. In: Proceedings of the ISMRM annual meeting (2017).
Di Trani MG, Caporale A, Nezzo M, Miano R, Mauriello A, Bove P, Manenti G, Capuani S. Non-Gaussian diffusion NMR discriminates between low- and high-risk prostate cancer. In: Proceedings of the third Edition of Biophysics@Rome (2017).
Di Trani MG, Monti S, Cavaliere C, Aiello M, Capuani S. About the dependence of Gaussian diffusion and Kurtosis parameters on SNR in prostate DWIs. In: Magnetic Resonance Materials in Physics, Biology and Medicine. Vol.30 (2017).Funding
Progetti di Avvio alla Ricerca 2018 - "Micro-imaging NMR ad alto campo (9.4 Tesla): studio e validazione dei parametri di diffusione molecolare sulla base delle microstrutture del tessuto sano e tumorale della prostata."
Progetti di Avvio alla Ricerca 2017 - "Sviluppo e validazione di nuove tecniche di imaging basate sull'NMR di diffusione molecolare applicate allo studio, diagnosi e stadiazione del tumore della prostata."